metaCluster - Metagenomic Clustering

Clustering in metagenomics is the process of grouping of microbial contigs in species specific bins. This package contains functions that extract genomic features from metagenome data, find the number of clusters for that given data and find the best clustering algorithm for binning.

Last updated 8 months ago

1.00 score 6 scripts 227 downloads

OpEnHiMR - Optimization Based Ensemble Model for Prediction of Histone Modifications in Rice

The comprehensive knowledge of epigenetic modifications in plants, encompassing histone modifications in regulating gene expression, is not completely ingrained. It is noteworthy that histone deacetylation and histone H3 lysine 27 trimethylation (H3K27me3) play a role in repressing transcription in eukaryotes. In contrast, histone acetylation (H3K9ac) and H3K4me3 have been inevitably linked to the stimulation of gene expression, which significantly influences plant development and plays a role in plant responses to biotic and abiotic stresses. To our knowledge this the first multiclass classifier for predicting histone modification in plants. <doi:10.1186/s12864-019-5489-4>.

Last updated 9 months ago

1.00 score 514 downloads

GB5mcPred - Gradient Boosting Algorithm for Predicting Methylation States

DNA methylation of 5-methylcytosine (5mC) is the result of a multi-step, enzyme-dependent process. Predicting these sites in-vitro is laborious, time consuming as well as costly. This ' Gb5mC-Pred ' package is an in-silico pipeline for predicting DNA sequences containing the 5mC sites. It uses a machine learning approach which uses Stochastic Gradient Boosting approach for prediction of the sequences with 5mC sites. This package has been developed by using the concept of Navarez and Roxas (2022) <doi:10.1109/TCBB.2021.3082184>.

Last updated 2 years ago

1.00 score 3 scripts 200 downloads

EpiSemble - Ensemble Based Machine Learning Approach for Predicting Methylation States

DNA methylation (6mA) is a major epigenetic process by which alteration in gene expression took place without changing the DNA sequence. Predicting these sites in-vitro is laborious, time consuming as well as costly. This 'EpiSemble' package is an in-silico pipeline for predicting DNA sequences containing the 6mA sites. It uses an ensemble-based machine learning approach by combining Support Vector Machine (SVM), Random Forest (RF) and Gradient Boosting approach to predict the sequences with 6mA sites in it. This package has been developed by using the concept of Chen et al. (2019) <doi:10.1093/bioinformatics/btz015>.

Last updated 2 years ago

1.00 score 1 stars 5 scripts 167 downloads